PIAS4

Gene Information

Official Symbol: PIAS4
Official Name: protein inhibitor of activated STAT 4
Aliases and Previous Symbols: N/A
Entrez ID: 51588
UniProt: Q8N2W9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Selumetinib 20μM R02 exp81	-2.59
Diepoxybutane 3μM R07 exp354	-2.3
BI-D1870 2μM R04 exp162	-2.28
I-BRD9 4μM R07 exp365	-2.19
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.16
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.08
Ethanol 0.01 R05 exp234	-2.06
Rapamycin 2μM plus FK-506 5μM R07 exp308	-2.06
Calcium Ionophore 0.4μM R07 exp342	-2.04
JQ1 0.8μM R08 exp435	-2.04
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.01
Epothilone-B 0.0015μM R05 exp231	-1.96
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.93
AICAR 240μM R03 exp116	-1.92
BI-D1870 3.15μM R02 exp66	-1.9
Radicicol 0.16μM R05 exp242	-1.89
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.8
VE-822 0.04μM R06 exp300	-1.79
Vinorelbine 0.001μM R05 exp249	-1.78
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.76
Tubacin 1.6μM R07 exp416	-1.75
Rapamycin 10μM R00 exp30	-1.74
CAY10603 0.55μM R08 exp467	-1.72
Oligomycin-A 2μM R00 exp25	-1.72
VER-155008 3.9μM R06 exp301	-1.72
ML-792 0.2μM R08 exp505	2.25

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12535
Expression level (log2 read counts): 4.87

Expression Distribution

Gene	Correlation
ERG	0.437
LMO2	0.432
SHOC2	0.404

positive regulation of keratinocyte apoptotic process
transferase complex
regulation of keratinocyte apoptotic process
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
SUMO ligase activity
positive regulation of protein sumoylation
vitamin D metabolic process
SUMO transferase activity
regulation of protein sumoylation
negative regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of epithelial cell apoptotic process
fat-soluble vitamin metabolic process
regulation of intrinsic apoptotic signaling pathway in response to DNA damage
double-strand break repair via nonhomologous end joining
regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
negative regulation of cytokine-mediated signaling pathway
RNA polymerase II transcription factor binding
non-recombinational repair
negative regulation of response to cytokine stimulus
protein sumoylation
regulation of epithelial cell apoptotic process
negative regulation of NF-kappaB transcription factor activity
transcription coregulator activity
positive regulation of response to DNA damage stimulus
PML body
nuclear matrix
vitamin metabolic process
positive regulation of protein modification by small protein conjugation or removal
regulation of intrinsic apoptotic signaling pathway
negative regulation of DNA-binding transcription factor activity
regulation of cytokine-mediated signaling pathway
positive regulation of apoptotic signaling pathway
regulation of response to cytokine stimulus
double-strand break repair
protein C-terminus binding
regulation of response to DNA damage stimulus
regulation of protein modification by small protein conjugation or removal
transcription corepressor activity
steroid metabolic process