PIGR [The Human Chemical-Genetic Interaction Map Project]

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======= PIGR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIGR
  * **<color #00a2e8>Official Name</color>**: polymeric immunoglobulin receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5284|5284]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01833|P01833]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIGR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIGR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173880|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polymeric immunoglobulin receptor activity|
|immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor|
|immune response in mucosal-associated lymphoid tissue|
|immunoglobulin transcytosis in epithelial cells|
|transcytosis|
|mucosal immune response|
|organ or tissue specific immune response|
|detection of chemical stimulus involved in sensory perception of bitter taste|
|sensory perception of bitter taste|
|receptor clustering|
|detection of chemical stimulus involved in sensory perception of taste|
|epidermal growth factor receptor signaling pathway|
|azurophil granule membrane|
|sensory perception of taste|
|ERBB signaling pathway|
|retina homeostasis|
|localization within membrane|
|tissue homeostasis|
|receptor complex|
|Fc receptor signaling pathway|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|protein localization to membrane|
|immune response-regulating cell surface receptor signaling pathway|
|detection of chemical stimulus involved in sensory perception|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|detection of chemical stimulus|
|sensory perception of chemical stimulus|
|detection of stimulus involved in sensory perception|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|detection of stimulus|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|sensory perception|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|regulation of immune response|
|nervous system process|
|integral component of plasma membrane|
|cellular protein localization|
|extracellular space|
|cellular macromolecule localization|
|homeostatic process|
|regulation of immune system process|
|immune response|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.86|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.83|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.75|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8497
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIGR Expression in NALM6 Cells: 2.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>