PIGR

Gene Information

Official Symbol: PIGR
Official Name: polymeric immunoglobulin receptor
Aliases and Previous Symbols: N/A
Entrez ID: 5284
UniProt: P01833
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009].
UniProt Summary: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8497
Expression level (log2 read counts): 2.24

Expression Distribution

Screen	Score
PNU96415E 10μM R03 exp145	-1.86
Nicotine 3000μM R08 exp510	-1.83
Heregulin-B 44ng/ml R08 exp486	-1.75
MS094 2μM R03 exp136	1.7

polymeric immunoglobulin receptor activity
immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
immune response in mucosal-associated lymphoid tissue
immunoglobulin transcytosis in epithelial cells
transcytosis
mucosal immune response
organ or tissue specific immune response
detection of chemical stimulus involved in sensory perception of bitter taste
sensory perception of bitter taste
receptor clustering
detection of chemical stimulus involved in sensory perception of taste
epidermal growth factor receptor signaling pathway
azurophil granule membrane
sensory perception of taste
ERBB signaling pathway
retina homeostasis
localization within membrane
tissue homeostasis
receptor complex
Fc receptor signaling pathway
multicellular organismal homeostasis
anatomical structure homeostasis
protein localization to membrane
immune response-regulating cell surface receptor signaling pathway
detection of chemical stimulus involved in sensory perception
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
transmembrane receptor protein tyrosine kinase signaling pathway
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
detection of chemical stimulus
sensory perception of chemical stimulus
detection of stimulus involved in sensory perception
myeloid leukocyte activation
immune response-regulating signaling pathway
leukocyte activation involved in immune response