PIGS [The Human Chemical-Genetic Interaction Map Project]

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======= PIGS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIGS
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol glycan anchor biosynthesis class S
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=94005|94005]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96S52|Q96S52]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIGS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIGS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610271|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. {ECO:0000269|PubMed:11483512}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PIG-S|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GPI-anchor transamidase complex|
|GPI-anchor transamidase activity|
|attachment of GPI anchor to protein|
|GPI anchor biosynthetic process|
|GPI anchor metabolic process|
|glycolipid biosynthetic process|
|protein lipidation|
|lipoprotein biosynthetic process|
|glycolipid metabolic process|
|phosphatidylinositol biosynthetic process|
|liposaccharide metabolic process|
|lipoprotein metabolic process|
|membrane lipid biosynthetic process|
|phosphatidylinositol metabolic process|
|membrane lipid metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.74|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.88|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.89|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.539|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.525|
|[[:human genes:t:tceb3c|TCEB3C]]|0.512|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.501|
|[[:human genes:o:orc1|ORC1]]|0.498|
|[[:human genes:p:polr2j3|POLR2J3]]|0.479|
|[[:human genes:m:mt1e|MT1E]]|0.472|
|[[:human genes:v:vasn|VASN]]|0.467|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.465|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.462|
|[[:human genes:t:ticrr|TICRR]]|0.461|
|[[:human genes:a:atp6ap2|ATP6AP2]]|0.459|
|[[:human genes:c:c14orf93|C14orf93]]|0.456|
|[[:human genes:p:psma6|PSMA6]]|0.456|
|[[:human genes:n:nupl1|NUPL1]]|0.454|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.453|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.449|
|[[:human genes:p:psmb2|PSMB2]]|0.449|
|[[:human genes:c:cbwd3|CBWD3]]|0.445|
|[[:human genes:r:rrp7a|RRP7A]]|0.443|
|[[:human genes:c:copa|COPA]]|0.438|
|[[:human genes:c:chd4|CHD4]]|0.437|
|[[:human genes:a:aatf|AATF]]|0.437|
|[[:human genes:p:psmd3|PSMD3]]|0.434|
|[[:human genes:o:orc6|ORC6]]|0.433|
|[[:human genes:w:wdr87|WDR87]]|0.432|
|[[:human genes:n:nup205|NUP205]]|0.432|
|[[:human genes:n:npipb5|NPIPB5]]|0.431|
|[[:human genes:p:pan2|PAN2]]|0.428|
|[[:human genes:f:fbxw9|FBXW9]]|0.425|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.424|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.424|
|[[:human genes:s:slc6a17|SLC6A17]]|0.423|
|[[:human genes:c:cbwd5|CBWD5]]|0.423|
|[[:human genes:z:znf830|ZNF830]]|0.423|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.422|
|[[:human genes:s:slc4a1|SLC4A1]]|0.422|
|[[:human genes:t:twistnb|TWISTNB]]|0.421|
|[[:human genes:n:nfatc4|NFATC4]]|0.419|
|[[:human genes:t:timeless|TIMELESS]]|0.417|
|[[:human genes:c:cdca5|CDCA5]]|0.416|
|[[:human genes:d:dock6|DOCK6]]|0.415|
|[[:human genes:n:nup160|NUP160]]|0.41|
|[[:human genes:s:snrpa1|SNRPA1]]|0.41|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.41|
|[[:human genes:l:lrr1|LRR1]]|0.41|
|[[:human genes:s:supt6h|SUPT6H]]|0.41|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.409|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.409|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.409|
|[[:human genes:p:psmc6|PSMC6]]|0.408|
|[[:human genes:p:pan3|PAN3]]|0.408|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.408|
|[[:human genes:t:terf2|TERF2]]|0.407|
|[[:human genes:s:smg1|SMG1]]|0.407|
|[[:human genes:k:klhl1|KLHL1]]|0.407|
|[[:human genes:c:cbwd6|CBWD6]]|0.407|
|[[:human genes:d:dtl|DTL]]|0.403|
|[[:human genes:r:ranbp2|RANBP2]]|0.403|
|[[:human genes:k:krt78|KRT78]]|0.401|
|[[:human genes:p:pole|POLE]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2194
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIGS Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>