PIGS

Entrez Summary: N/A
UniProt Summary: Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. {ECO:0000269|PubMed:11483512}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.74
S-trityl-L-cysteine 0.5μM R05 exp243	1.88
Docetaxel 0.002μM R01 exp45	1.89
BI-2536 0.001μM R01 exp41	2.03

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GPI-anchor transamidase complex
GPI-anchor transamidase activity
attachment of GPI anchor to protein
GPI anchor biosynthetic process
GPI anchor metabolic process
glycolipid biosynthetic process
protein lipidation
lipoprotein biosynthetic process
glycolipid metabolic process
phosphatidylinositol biosynthetic process
liposaccharide metabolic process
lipoprotein metabolic process
membrane lipid biosynthetic process
phosphatidylinositol metabolic process
membrane lipid metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
carbohydrate derivative biosynthetic process
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane