PIGU [The Human Chemical-Genetic Interaction Map Project]

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======= PIGU =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIGU
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol glycan anchor biosynthesis class U
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=128869|128869]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H490|Q9H490]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIGU&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIGU|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608528|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI. {ECO:0000269|PubMed:12802054}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PIG-U|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GPI-anchor transamidase complex|
|GPI-anchor transamidase activity|
|attachment of GPI anchor to protein|
|GPI anchor binding|
|protein localization to cell surface|
|GPI anchor biosynthetic process|
|GPI anchor metabolic process|
|glycolipid biosynthetic process|
|protein lipidation|
|lipoprotein biosynthetic process|
|integral component of endoplasmic reticulum membrane|
|phosphatidylinositol biosynthetic process|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|lipoprotein metabolic process|
|regulation of receptor signaling pathway via JAK-STAT|
|membrane lipid biosynthetic process|
|regulation of receptor signaling pathway via STAT|
|phosphatidylinositol metabolic process|
|membrane lipid metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular protein localization|
|cellular macromolecule localization|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|1.79|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.87|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9728
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIGU Expression in NALM6 Cells: 4.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>