PIGU

Entrez Summary: The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008].
UniProt Summary: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI. {ECO:0000269|PubMed:12802054}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GPI-anchor transamidase complex
GPI-anchor transamidase activity
attachment of GPI anchor to protein
GPI anchor binding
protein localization to cell surface
GPI anchor biosynthetic process
GPI anchor metabolic process
glycolipid biosynthetic process
protein lipidation
lipoprotein biosynthetic process
integral component of endoplasmic reticulum membrane
phosphatidylinositol biosynthetic process
glycolipid metabolic process
liposaccharide metabolic process
lipoprotein metabolic process
regulation of receptor signaling pathway via JAK-STAT
membrane lipid biosynthetic process
regulation of receptor signaling pathway via STAT
phosphatidylinositol metabolic process
membrane lipid metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
carbohydrate derivative biosynthetic process
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
cellular protein localization
cellular macromolecule localization
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane