PIM2

Gene Information

Official Symbol: PIM2
Official Name: Pim-2 proto-oncogene, serine/threonine kinase
Aliases and Previous Symbols: N/A
Entrez ID: 11040
UniProt: Q9P1W9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009].
UniProt Summary: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti- apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate. {ECO:0000269|PubMed:18593906, ECO:0000269|PubMed:18675992, ECO:0000269|PubMed:20307683}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 8/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	6/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18327
Expression level (log2 read counts): 4.12

Expression Distribution

Pkinase Tyr
Pkinase

apoptotic mitochondrial changes
positive regulation of macroautophagy
negative regulation of protein binding
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
positive regulation of autophagy
negative regulation of binding
regulation of macroautophagy
protein stabilization
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein autophosphorylation
regulation of protein binding
regulation of I-kappaB kinase/NF-kappaB signaling
mitotic cell cycle phase transition
cell cycle phase transition
response to virus
regulation of protein stability
regulation of autophagy
protein serine/threonine kinase activity
positive regulation of cellular catabolic process
regulation of binding
positive regulation of catabolic process
mitochondrion organization
mitotic cell cycle process
negative regulation of cell population proliferation
mitotic cell cycle
regulation of cellular catabolic process
negative regulation of apoptotic process
negative regulation of programmed cell death
apoptotic process
protein phosphorylation
regulation of catabolic process
negative regulation of cell death
cell cycle process
positive regulation of intracellular signal transduction
programmed cell death
cell death
negative regulation of molecular function
phosphorylation
response to other organism