PIM3

Entrez Summary: N/A
UniProt Summary: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. {ECO:0000269|PubMed:15540201, ECO:0000269|PubMed:16818649, ECO:0000269|PubMed:17270021, ECO:0000269|PubMed:17876606, ECO:0000269|PubMed:18593906}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of insulin secretion
negative regulation of peptide hormone secretion
regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of hormone secretion
negative regulation of protein secretion
negative regulation of peptide secretion
regulation of insulin secretion
negative regulation of protein transport
negative regulation of establishment of protein localization
protein autophosphorylation
negative regulation of secretion by cell
regulation of peptide hormone secretion
negative regulation of secretion
regulation of hormone secretion
protein serine/threonine kinase activity
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion
regulation of hormone levels
regulation of mitotic cell cycle
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of secretion
negative regulation of apoptotic process
negative regulation of programmed cell death
regulation of cellular localization
apoptotic process
protein phosphorylation
negative regulation of cell death
regulation of protein localization
programmed cell death
cell death
regulation of cell cycle
phosphorylation
cell cycle
negative regulation of cell communication
negative regulation of signaling