PIRT

Official Symbol: PIRT
Official Name: phosphoinositide interacting regulator of transient receptor potential channels
Aliases and Previous Symbols: N/A
Entrez ID: 644139
UniProt: P0C851
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5- bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylinositol bisphosphate binding
behavioral response to pain
response to pain
phosphatidylinositol-3,4,5-trisphosphate binding
multicellular organismal response to stress
positive regulation of cation channel activity
phosphatidylinositol-mediated signaling
inositol lipid-mediated signaling
positive regulation of ion transmembrane transporter activity
response to heat
positive regulation of transporter activity
ion channel binding
positive regulation of cation transmembrane transport
positive regulation of ion transmembrane transport
regulation of cation channel activity
response to temperature stimulus
positive regulation of transmembrane transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
positive regulation of ion transport
regulation of transporter activity
regulation of cation transmembrane transport
regulation of ion transmembrane transport
regulation of transmembrane transport
behavior
regulation of ion transport
positive regulation of transport
response to abiotic stimulus
intracellular signal transduction
positive regulation of molecular function
regulation of transport