PITPNA

Entrez Summary: This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase.[provided by RefSeq, Sep 2009].
UniProt Summary: Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylglycerol binding
phosphatidylcholine transporter activity
phosphatidylinositol transfer activity
phosphatidylcholine binding
interleukin-12-mediated signaling pathway
cellular response to interleukin-12
response to interleukin-12
phosphatidylinositol binding
phospholipid transport
organophosphate ester transport
visual perception
sensory perception of light stimulus
lipid transport
lipid localization
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
organic anion transport
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
cell morphogenesis involved in differentiation
anion transport
neuron projection development
cytokine-mediated signaling pathway
cell morphogenesis
neuron development
cellular component morphogenesis
sensory perception
cellular response to cytokine stimulus
neuron differentiation
response to cytokine
plasma membrane bounded cell projection organization
cell projection organization
lipid metabolic process
ion transport
nervous system process
generation of neurons
neurogenesis