PITRM1 [The Human Chemical-Genetic Interaction Map Project]

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======= PITRM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PITRM1
  * **<color #00a2e8>Official Name</color>**: pitrilysin metallopeptidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10531|10531]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5JRX3|Q5JRX3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PITRM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PITRM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618211|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|M16C assoc|
|Peptidase M16 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enzyme activator activity|
|protein targeting to mitochondrion|
|metallopeptidase activity|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|metalloendopeptidase activity|
|protein processing|
|mitochondrial transport|
|protein maturation|
|protein targeting|
|mitochondrial matrix|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to organelle|
|zinc ion binding|
|intracellular protein transport|
|mitochondrion|
|proteolysis|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.64|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.95|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.88|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.79|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.7|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.75|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.77|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.78|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.78|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.81|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.83|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.91|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.95|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.02|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.02|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.11|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.14|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.15|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gfm2|GFM2]]|0.517|
|[[:human genes:m:mrps5|MRPS5]]|0.493|
|[[:human genes:e:ears2|EARS2]]|0.486|
|[[:human genes:m:mrpl23|MRPL23]]|0.482|
|[[:human genes:t:timm17a|TIMM17A]]|0.482|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.469|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.468|
|[[:human genes:w:wars2|WARS2]]|0.465|
|[[:human genes:y:yars2|YARS2]]|0.465|
|[[:human genes:m:mrps6|MRPS6]]|0.464|
|[[:human genes:q:qrsl1|QRSL1]]|0.463|
|[[:human genes:p:pet112|PET112]]|0.459|
|[[:human genes:c:coq3|COQ3]]|0.459|
|[[:human genes:c:c12orf65|C12orf65]]|0.454|
|[[:human genes:w:wbscr16|WBSCR16]]|0.454|
|[[:human genes:t:timm8b|TIMM8B]]|0.45|
|[[:human genes:s:selrc1|SELRC1]]|0.45|
|[[:human genes:m:mtg1|MTG1]]|0.446|
|[[:human genes:d:dnlz|DNLZ]]|0.443|
|[[:human genes:m:mrpl21|MRPL21]]|0.442|
|[[:human genes:m:mrps34|MRPS34]]|0.441|
|[[:human genes:p:polg|POLG]]|0.441|
|[[:human genes:c:coq2|COQ2]]|0.44|
|[[:human genes:c:cox11|COX11]]|0.44|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.439|
|[[:human genes:r:rbfa|RBFA]]|0.436|
|[[:human genes:m:mettl17|METTL17]]|0.436|
|[[:human genes:f:ftsj2|FTSJ2]]|0.435|
|[[:human genes:t:trmt61a|TRMT61A]]|0.433|
|[[:human genes:t:trmt10a|TRMT10A]]|0.433|
|[[:human genes:h:hars2|HARS2]]|0.431|
|[[:human genes:m:mrpl44|MRPL44]]|0.43|
|[[:human genes:p:pars2|PARS2]]|0.43|
|[[:human genes:m:mrpl47|MRPL47]]|0.43|
|[[:human genes:l:lars2|LARS2]]|0.426|
|[[:human genes:m:mcat|MCAT]]|0.424|
|[[:human genes:m:mrps26|MRPS26]]|0.424|
|[[:human genes:m:mtg2|MTG2]]|0.423|
|[[:human genes:d:dap3|DAP3]]|0.422|
|[[:human genes:m:mrps14|MRPS14]]|0.421|
|[[:human genes:m:mrps23|MRPS23]]|0.42|
|[[:human genes:m:mrpl4|MRPL4]]|0.42|
|[[:human genes:i:iba57|IBA57]]|0.42|
|[[:human genes:m:mrps16|MRPS16]]|0.42|
|[[:human genes:c:coa6|COA6]]|0.419|
|[[:human genes:t:tars2|TARS2]]|0.418|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.418|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.418|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.417|
|[[:human genes:f:fastkd1|FASTKD1]]|0.417|
|[[:human genes:n:ndufb11|NDUFB11]]|0.416|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.415|
|[[:human genes:m:mrpl15|MRPL15]]|0.409|
|[[:human genes:n:nars2|NARS2]]|0.406|
|[[:human genes:t:tomm20|TOMM20]]|0.405|
|[[:human genes:c:coq6|COQ6]]|0.405|
|[[:human genes:a:aars2|AARS2]]|0.404|
|[[:human genes:m:mrps18a|MRPS18A]]|0.402|
|[[:human genes:c:coq5|COQ5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2515
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PITRM1 Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>