PITRM1

Entrez Summary: The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease. [provided by RefSeq, Dec 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK-J4 1μM R07 exp362	-2.64
UM0011500 5μM R05 exp245	-1.95
HMS-I2 1μM R06 exp286	-1.88
Dimethyloxaloylglycine 11μM R07 exp314	-1.79
Resveratrol 16μM R03 exp147	1.7
Vinblastine 0.002μM R01 exp60	1.75
Taxol 0.004μM R03 exp103	1.77
Milciclib 2μM R08 exp502	1.78
Quercetin 20μM R08 exp517	1.78
GSK-J4 1.5μM R08 exp441	1.81
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.83
Aphidicolin 0.4μM R08 exp440	1.91
BI-2536 0.0042μM R03 exp95	1.95
BI-6727 0.0125μM R03 exp97	2.02
Thimerosal 0.85μM R08 exp529	2.02
TIC10 10μM R08 exp532	2.11
ONC212 0.15μM R08 exp513	2.14
JQ1 0.8μM R08 exp435	2.15
CoCl2 18μM R07 exp346	2.46

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

M16C assoc
Peptidase M16 C

enzyme activator activity
protein targeting to mitochondrion
metallopeptidase activity
establishment of protein localization to mitochondrion
protein localization to mitochondrion
metalloendopeptidase activity
protein processing
mitochondrial transport
protein maturation
protein targeting
mitochondrial matrix
establishment of protein localization to organelle
mitochondrion organization
protein localization to organelle
zinc ion binding
intracellular protein transport
mitochondrion
proteolysis
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
positive regulation of molecular function
establishment of localization in cell
nitrogen compound transport
gene expression