PITX3

Gene Information

Official Symbol: PITX3
Official Name: paired like homeodomain 3
Aliases and Previous Symbols: N/A
Entrez ID: 5309
UniProt: O75364
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts. [provided by RefSeq, Jul 2008].
UniProt Summary: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1- mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12643
Expression level (log2 read counts): -4.6

Expression Distribution

Homeobox
OAR

cellular response to glial cell derived neurotrophic factor
response to glial cell derived neurotrophic factor
positive regulation of cell proliferation in midbrain
regulation of cell proliferation in midbrain
response to methamphetamine hydrochloride
response to salt
lens morphogenesis in camera-type eye
response to immobilization stress
lens fiber cell differentiation
dopaminergic neuron differentiation
response to morphine
response to isoquinoline alkaloid
negative regulation of gliogenesis
positive regulation of neural precursor cell proliferation
positive regulation of neuron apoptotic process
response to cocaine
RNA polymerase II transcription factor binding
lens development in camera-type eye
response to anesthetic
midbrain development
regulation of neural precursor cell proliferation
positive regulation of neuron death
camera-type eye morphogenesis
response to alkaloid
regulation of gliogenesis
eye morphogenesis
response to ammonium ion
locomotory behavior
regulation of neuron apoptotic process
sensory organ morphogenesis
aging
negative regulation of neurogenesis
response to xenobiotic stimulus
regulation of neuron death
negative regulation of nervous system development
camera-type eye development
negative regulation of cell development
eye development
visual system development
sensory system development