PKIB

Gene Information

Official Symbol: PKIB
Official Name: cAMP-dependent protein kinase inhibitor beta
Aliases and Previous Symbols: N/A
Entrez ID: 5570
UniProt: Q9C010
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16348
Expression level (log2 read counts): 0.87

Expression Distribution

negative regulation of cAMP-dependent protein kinase activity
cAMP-dependent protein kinase inhibitor activity
regulation of cAMP-dependent protein kinase activity
positive regulation of telomere capping
regulation of telomere capping
positive regulation of telomere maintenance via telomerase
positive regulation of telomerase activity
positive regulation of telomere maintenance via telomere lengthening
positive regulation of telomere maintenance
regulation of telomerase activity
regulation of telomere maintenance via telomerase
regulation of telomere maintenance via telomere lengthening
positive regulation of DNA biosynthetic process
regulation of telomere maintenance
regulation of DNA biosynthetic process
negative regulation of protein serine/threonine kinase activity
positive regulation of chromosome organization
positive regulation of DNA metabolic process
negative regulation of protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
regulation of chromosome organization
regulation of DNA metabolic process
negative regulation of protein phosphorylation
negative regulation of phosphorylation
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
positive regulation of organelle organization
positive regulation of transferase activity
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
positive regulation of cellular component organization
regulation of organelle organization