PKLR [The Human Chemical-Genetic Interaction Map Project]

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======= PKLR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PKLR
  * **<color #00a2e8>Official Name</color>**: pyruvate kinase L/R
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5313|5313]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30613|P30613]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PKLR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PKLR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609712|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a key role in glycolysis. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PK C|
|PK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pyruvate kinase activity|
|pyruvate biosynthetic process|
|potassium ion binding|
|cellular response to epinephrine stimulus|
|response to epinephrine|
|response to lithium ion|
|canonical glycolysis|
|NADH regeneration|
|glucose catabolic process to pyruvate|
|glycolytic process through fructose-6-phosphate|
|glycolytic process through glucose-6-phosphate|
|glucose catabolic process|
|response to ATP|
|ATP biosynthetic process|
|NADH metabolic process|
|glycolytic process|
|ATP generation from ADP|
|purine ribonucleoside triphosphate biosynthetic process|
|NAD metabolic process|
|purine nucleoside triphosphate biosynthetic process|
|ADP metabolic process|
|ribonucleoside triphosphate biosynthetic process|
|hexose catabolic process|
|nucleoside diphosphate phosphorylation|
|purine ribonucleoside triphosphate metabolic process|
|purine nucleoside diphosphate metabolic process|
|monosaccharide catabolic process|
|purine ribonucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside diphosphate metabolic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|pyruvate metabolic process|
|kinase activity|
|nucleoside diphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|response to cAMP|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|response to catecholamine|
|response to monoamine|
|response to heat|
|glucose metabolic process|
|carbohydrate catabolic process|
|response to organophosphorus|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|purine ribonucleotide biosynthetic process|
|response to purine-containing compound|
|purine nucleotide biosynthetic process|
|hexose metabolic process|
|ribonucleotide biosynthetic process|
|cellular response to insulin stimulus|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|response to carbohydrate|
|response to temperature stimulus|
|monocarboxylic acid biosynthetic process|
|monosaccharide metabolic process|
|ATP metabolic process|
|magnesium ion binding|
|response to nutrient|
|response to insulin|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|cellular response to peptide hormone stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|purine ribonucleotide metabolic process|
|cellular response to peptide|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|response to hypoxia|
|response to decreased oxygen levels|
|purine-containing compound metabolic process|
|response to metal ion|
|response to oxygen levels|
|response to peptide hormone|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|response to peptide|
|carbohydrate metabolic process|
|response to nutrient levels|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|response to inorganic substance|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cellular response to organic cyclic compound|
|small molecule biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|carbohydrate derivative biosynthetic process|
|cellular response to nitrogen compound|
|organophosphate metabolic process|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|oxidation-reduction process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6564
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PKLR Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>