PKLR

Entrez Summary: The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Plays a key role in glycolysis. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

pyruvate kinase activity
pyruvate biosynthetic process
potassium ion binding
cellular response to epinephrine stimulus
response to epinephrine
response to lithium ion
canonical glycolysis
NADH regeneration
glucose catabolic process to pyruvate
glycolytic process through fructose-6-phosphate
glycolytic process through glucose-6-phosphate
glucose catabolic process
response to ATP
ATP biosynthetic process
NADH metabolic process
glycolytic process
ATP generation from ADP
purine ribonucleoside triphosphate biosynthetic process
NAD metabolic process
purine nucleoside triphosphate biosynthetic process
ADP metabolic process
ribonucleoside triphosphate biosynthetic process
hexose catabolic process
nucleoside diphosphate phosphorylation
purine ribonucleoside triphosphate metabolic process
purine nucleoside diphosphate metabolic process
monosaccharide catabolic process
purine ribonucleoside diphosphate metabolic process
nucleotide phosphorylation
nucleoside triphosphate biosynthetic process
ribonucleoside diphosphate metabolic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
pyruvate metabolic process
kinase activity
nucleoside diphosphate metabolic process
nucleoside triphosphate metabolic process
response to cAMP
cellular response to catecholamine stimulus
cellular response to monoamine stimulus