PKN2 [The Human Chemical-Genetic Interaction Map Project]

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======= PKN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PKN2
  * **<color #00a2e8>Official Name</color>**: protein kinase N2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5586|5586]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16513|Q16513]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PKN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PKN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602549|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c- fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase C|
|Pkinase Tyr|
|HR1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein kinase C activity|
|RNA polymerase binding|
|apical junction complex|
|GTP-Rho binding|
|positive regulation of viral genome replication|
|positive regulation of cytokinesis|
|apical junction assembly|
|intermediate filament cytoskeleton|
|cleavage furrow|
|positive regulation of viral life cycle|
|kinase activity|
|epithelial cell migration|
|epithelium migration|
|positive regulation of cell division|
|regulation of cytokinesis|
|tissue migration|
|regulation of viral genome replication|
|cell-cell junction assembly|
|positive regulation of viral process|
|histone deacetylase binding|
|cell-cell junction organization|
|regulation of viral life cycle|
|positive regulation of mitotic cell cycle|
|midbody|
|regulation of cell division|
|cell junction assembly|
|ameboidal-type cell migration|
|peptidyl-serine phosphorylation|
|lamellipodium|
|peptidyl-serine modification|
|regulation of viral process|
|cell junction organization|
|regulation of symbiosis, encompassing mutualism through parasitism|
|protein kinase activity|
|nuclear body|
|positive regulation of cell cycle process|
|cadherin binding|
|protein serine/threonine kinase activity|
|positive regulation of cell cycle|
|centrosome|
|cell division|
|positive regulation of multi-organism process|
|protein-containing complex|
|regulation of mitotic cell cycle|
|perinuclear region of cytoplasm|
|viral process|
|regulation of cell cycle process|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|peptidyl-amino acid modification|
|regulation of cell motility|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|cell migration|
|protein phosphorylation|
|regulation of locomotion|
|regulation of cellular component movement|
|programmed cell death|
|cell motility|
|localization of cell|
|cell death|
|cell projection organization|
|regulation of cell cycle|
|phosphorylation|
|locomotion|
|cell cycle|
|RNA binding|
|ATP binding|
|movement of cell or subcellular component|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16187
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PKN2 Expression in NALM6 Cells: 6.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>