PKN2

Gene Information

Official Symbol: PKN2
Official Name: protein kinase N2
Aliases and Previous Symbols: N/A
Entrez ID: 5586
UniProt: Q16513
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c- fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16187
Expression level (log2 read counts): 6.64

Expression Distribution

Pkinase
Pkinase C
Pkinase Tyr
HR1

protein kinase C activity
RNA polymerase binding
apical junction complex
GTP-Rho binding
positive regulation of viral genome replication
positive regulation of cytokinesis
apical junction assembly
intermediate filament cytoskeleton
cleavage furrow
positive regulation of viral life cycle
kinase activity
epithelial cell migration
epithelium migration
positive regulation of cell division
regulation of cytokinesis
tissue migration
regulation of viral genome replication
cell-cell junction assembly
positive regulation of viral process
histone deacetylase binding
cell-cell junction organization
regulation of viral life cycle
positive regulation of mitotic cell cycle
midbody
regulation of cell division
cell junction assembly
ameboidal-type cell migration
peptidyl-serine phosphorylation
lamellipodium
peptidyl-serine modification
regulation of viral process
cell junction organization
regulation of symbiosis, encompassing mutualism through parasitism
protein kinase activity
nuclear body
positive regulation of cell cycle process
cadherin binding
protein serine/threonine kinase activity
positive regulation of cell cycle
centrosome