PKP4

Entrez Summary: N/A
UniProt Summary: Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell-cell contact zone
desmosome
spindle midzone
positive regulation of cytokinesis
cytoplasmic side of plasma membrane
cornified envelope
mitotic spindle
positive regulation of cell division
regulation of cytokinesis
cell-cell adherens junction
cell-cell junction assembly
cornification
spindle pole
cell-cell junction organization
midbody
regulation of cell division
cell junction assembly
cell-cell junction
cell junction organization
keratinization
postsynaptic density
keratinocyte differentiation
positive regulation of cell cycle process
cadherin binding
epidermal cell differentiation
cytoskeleton
positive regulation of cell cycle
skin development
positive regulation of GTPase activity
epidermis development
regulation of GTPase activity
cell-cell adhesion
cell junction
epithelial cell differentiation
regulation of cell adhesion
perinuclear region of cytoplasm
regulation of cell cycle process
positive regulation of hydrolase activity
cell adhesion
biological adhesion