PLA2G12A

Entrez Summary: N/A
UniProt Summary: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine. {ECO:0000269|PubMed:12522102}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rapamycin 0.001μM R08 exp429	1.71
PU-H71 1μM R08 exp515	1.79

calcium-dependent phospholipase A2 activity
phosphatidylinositol acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
arachidonate transport
arachidonic acid secretion
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phosphatidylethanolamine acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
icosanoid secretion
phospholipase A2 activity
phosphatidylglycerol metabolic process
fatty acid derivative transport
icosanoid transport
phosphatidylserine metabolic process
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
long-chain fatty acid transport
fatty acid transport
phosphatidylcholine metabolic process
acid secretion
monocarboxylic acid transport
phosphatidylinositol metabolic process
ammonium ion metabolic process
cellular modified amino acid metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
carboxylic acid transport
organic acid transport
lipid transport
lipid catabolic process
glycerophospholipid metabolic process
lipid localization
phospholipid metabolic process
glycerolipid metabolic process
organic anion transport
organophosphate biosynthetic process
lipid biosynthetic process