PLA2G2A [The Human Chemical-Genetic Interaction Map Project]

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======= PLA2G2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLA2G2A
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 group IIA
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5320|5320]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14555|P14555]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2G2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2G2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172411|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536). {ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:2925633}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Phospholip A2 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|low-density lipoprotein particle remodeling|
|positive regulation of macrophage derived foam cell differentiation|
|calcium-dependent phospholipase A2 activity|
|phosphatidylinositol acyl-chain remodeling|
|phosphatidylglycerol acyl-chain remodeling|
|phosphatidylserine acyl-chain remodeling|
|arachidonate transport|
|arachidonic acid secretion|
|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|
|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|
|phosphatidylethanolamine acyl-chain remodeling|
|icosanoid secretion|
|phosphatidylcholine acyl-chain remodeling|
|plasma lipoprotein particle remodeling|
|phospholipase A2 activity|
|protein-lipid complex remodeling|
|protein-containing complex remodeling|
|regulation of macrophage derived foam cell differentiation|
|phosphatidylglycerol metabolic process|
|fatty acid derivative transport|
|icosanoid transport|
|phosphatidylserine metabolic process|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|plasma lipoprotein particle organization|
|protein-lipid complex subunit organization|
|long-chain fatty acid transport|
|regulation of plasma lipoprotein particle levels|
|fatty acid transport|
|phosphatidylcholine metabolic process|
|acid secretion|
|secretory granule|
|defense response to Gram-positive bacterium|
|phospholipid binding|
|antimicrobial humoral response|
|monocarboxylic acid transport|
|positive regulation of inflammatory response|
|phosphatidylinositol metabolic process|
|ammonium ion metabolic process|
|cellular modified amino acid metabolic process|
|glycerophospholipid biosynthetic process|
|positive regulation of ERK1 and ERK2 cascade|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|organic acid transport|
|carboxylic acid transport|
|regulation of ERK1 and ERK2 cascade|
|lipid transport|
|lipid catabolic process|
|glycerophospholipid metabolic process|
|lipid localization|
|defense response to bacterium|
|regulation of inflammatory response|
|humoral immune response|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|extracellular structure organization|
|organic anion transport|
|positive regulation of defense response|
|organophosphate biosynthetic process|
|positive regulation of MAPK cascade|
|lipid biosynthetic process|
|anion transport|
|positive regulation of response to external stimulus|
|response to bacterium|
|perinuclear region of cytoplasm|
|calcium ion binding|
|regulation of MAPK cascade|
|regulation of defense response|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|defense response to other organism|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|lipid metabolic process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|ion transport|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.26|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.7|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.77|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.83|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.88|
|[[:results:exp461|BS-181 20μM R08 exp461]]|2.38|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7518
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2G2A Expression in NALM6 Cells: -3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>