PLA2G2A

Gene Information

Official Symbol: PLA2G2A
Official Name: phospholipase A2 group IIA
Aliases and Previous Symbols: N/A
Entrez ID: 5320
UniProt: P14555
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009].
UniProt Summary: Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536). {ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:2925633}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Calcium Ionophore 0.4μM R07 exp342	-2.26
WYE-354 6μM R02 exp90	1.7
UM0131023 0.05μM R05 exp248	1.77
Vinorelbine 0.001μM R05 exp249	1.83
Taxol 0.004μM R03 exp103	1.88
BS-181 20μM R08 exp461	2.38
Betulinic acid 10 to 15μM on day4 R05 exp222	2.47

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7518
Expression level (log2 read counts): -3.8

Expression Distribution

low-density lipoprotein particle remodeling
positive regulation of macrophage derived foam cell differentiation
calcium-dependent phospholipase A2 activity
phosphatidylinositol acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
arachidonate transport
arachidonic acid secretion
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phosphatidylethanolamine acyl-chain remodeling
icosanoid secretion
phosphatidylcholine acyl-chain remodeling
plasma lipoprotein particle remodeling
phospholipase A2 activity
protein-lipid complex remodeling
protein-containing complex remodeling
regulation of macrophage derived foam cell differentiation
phosphatidylglycerol metabolic process
fatty acid derivative transport
icosanoid transport
phosphatidylserine metabolic process
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
plasma lipoprotein particle organization
protein-lipid complex subunit organization
long-chain fatty acid transport
regulation of plasma lipoprotein particle levels
fatty acid transport
phosphatidylcholine metabolic process
acid secretion
secretory granule
defense response to Gram-positive bacterium
phospholipid binding
antimicrobial humoral response
monocarboxylic acid transport
positive regulation of inflammatory response
phosphatidylinositol metabolic process
ammonium ion metabolic process
cellular modified amino acid metabolic process