PLA2G2F

Gene Information

Official Symbol: PLA2G2F
Official Name: phospholipase A2 group IIF
Aliases and Previous Symbols: N/A
Entrez ID: 64600
UniProt: Q9BZM2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference. {ECO:0000269|PubMed:11112443}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11062
Expression level (log2 read counts): -4.79

Expression Distribution

calcium-dependent phospholipase A2 activity
phosphatidylinositol acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
arachidonic acid secretion
arachidonate transport
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phosphatidylethanolamine acyl-chain remodeling
icosanoid secretion
phosphatidylcholine acyl-chain remodeling
phospholipase A2 activity
phosphatidylglycerol metabolic process
fatty acid derivative transport
phosphatidylserine metabolic process
icosanoid transport
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
long-chain fatty acid transport
negative regulation of T cell proliferation
fatty acid transport
negative regulation of lymphocyte proliferation
negative regulation of mononuclear cell proliferation
phosphatidylcholine metabolic process
negative regulation of leukocyte proliferation
acid secretion
phospholipid binding
negative regulation of T cell activation
negative regulation of leukocyte cell-cell adhesion
monocarboxylic acid transport
negative regulation of lymphocyte activation
regulation of T cell proliferation
phosphatidylinositol metabolic process
negative regulation of leukocyte activation
negative regulation of cell-cell adhesion
ammonium ion metabolic process
negative regulation of cell activation
cellular modified amino acid metabolic process
glycerophospholipid biosynthetic process
regulation of lymphocyte proliferation