PLA2G4C

Entrez Summary: This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009].
UniProt Summary: Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:9705332}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

calcium-independent phospholipase A2 activity
phospholipase A1 activity
calcium-dependent phospholipase A2 activity
parturition
phosphatidylinositol acyl-chain remodeling
lysophospholipase activity
glycerophospholipid catabolic process
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phosphatidylethanolamine acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
phospholipase A2 activity
phospholipid catabolic process
glycerolipid catabolic process
calcium-dependent phospholipid binding
arachidonic acid metabolic process
phosphatidylcholine metabolic process
phospholipid binding
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
organophosphate catabolic process
cell cortex
fatty acid derivative metabolic process
phosphatidylinositol metabolic process
nuclear envelope
ammonium ion metabolic process
cellular lipid catabolic process
multi-multicellular organism process
lipid catabolic process
glycerophospholipid metabolic process
fatty acid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
inflammatory response
monocarboxylic acid metabolic process
calcium ion binding
organophosphate metabolic process
carboxylic acid metabolic process
endoplasmic reticulum membrane