PLB1

Entrez Summary: This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016].
UniProt Summary: Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

retinyl-palmitate esterase activity
positive regulation of acrosome reaction
positive regulation of fertilization
regulation of acrosome reaction
lysophospholipase activity
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phosphatidylcholine acyl-chain remodeling
phospholipase A2 activity
regulation of fertilization
retinol metabolic process
brush border membrane
phosphatidylcholine metabolic process
primary alcohol metabolic process
positive regulation of reproductive process
retinoid metabolic process
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
isoprenoid metabolic process
regulation of reproductive process
ammonium ion metabolic process
hormone metabolic process
lipid catabolic process
glycerophospholipid metabolic process
alcohol metabolic process
apical plasma membrane
phospholipid metabolic process
glycerolipid metabolic process
organic hydroxy compound metabolic process
positive regulation of multi-organism process
regulation of hormone levels
regulation of multi-organism process
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process
small molecule metabolic process
organic substance catabolic process