PLCG1 [The Human Chemical-Genetic Interaction Map Project]

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======= PLCG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLCG1
  * **<color #00a2e8>Official Name</color>**: phospholipase C gamma 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5335|5335]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19174|P19174]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLCG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLCG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172420|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. {ECO:0000269|PubMed:17229814}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH2|
|SH3 1|
|C2|
|PI-PLC-Y|
|PI-PLC-X|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurotrophin TRKA receptor binding|
|glutamate receptor binding|
|phospholipase C activity|
|positive regulation of vascular endothelial cell proliferation|
|inositol trisphosphate biosynthetic process|
|positive regulation of endothelial cell apoptotic process|
|inositol trisphosphate metabolic process|
|regulation of vascular endothelial cell proliferation|
|phosphatidylinositol phospholipase C activity|
|inositol phosphate biosynthetic process|
|activation of phospholipase C activity|
|positive regulation of epithelial cell apoptotic process|
|phospholipid catabolic process|
|COP9 signalosome|
|positive regulation of release of sequestered calcium ion into cytosol|
|cellular response to epidermal growth factor stimulus|
|positive regulation of phospholipase C activity|
|regulation of phospholipase C activity|
|response to epidermal growth factor|
|regulation of endothelial cell apoptotic process|
|epidermal growth factor receptor signaling pathway|
|positive regulation of calcium ion transport into cytosol|
|release of sequestered calcium ion into cytosol|
|positive regulation of blood vessel endothelial cell migration|
|receptor tyrosine kinase binding|
|inositol phosphate metabolic process|
|negative regulation of sequestering of calcium ion|
|polyol biosynthetic process|
|positive regulation of phospholipase activity|
|calcium ion transmembrane import into cytosol|
|ERBB signaling pathway|
|positive regulation of calcium ion transmembrane transport|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|phosphatidylinositol-mediated signaling|
|calcium ion transport into cytosol|
|inositol lipid-mediated signaling|
|regulation of release of sequestered calcium ion into cytosol|
|regulation of epithelial cell apoptotic process|
|Schaffer collateral - CA1 synapse|
|cytosolic calcium ion transport|
|regulation of blood vessel endothelial cell migration|
|ruffle|
|positive regulation of endothelial cell proliferation|
|regulation of lipase activity|
|cell projection|
|regulation of calcium ion transport into cytosol|
|positive regulation of endothelial cell migration|
|polyol metabolic process|
|alcohol biosynthetic process|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|organophosphate catabolic process|
|regulation of endothelial cell proliferation|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|positive regulation of epithelial cell migration|
|positive regulation of cation transmembrane transport|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|cell-cell junction|
|Fc-epsilon receptor signaling pathway|
|T cell receptor signaling pathway|
|lamellipodium|
|positive regulation of vasculature development|
|organic hydroxy compound biosynthetic process|
|positive regulation of epithelial cell proliferation|
|cellular lipid catabolic process|
|calcium ion transmembrane transport|
|positive regulation of transmembrane transport|
|regulation of epithelial cell migration|
|Fc receptor signaling pathway|
|regulation of calcium ion transport|
|calcium ion transport|
|axon guidance|
|neuron projection guidance|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|regulation of angiogenesis|
|antigen receptor-mediated signaling pathway|
|divalent metal ion transport|
|lipid catabolic process|
|divalent inorganic cation transport|
|alcohol metabolic process|
|regulation of vasculature development|
|regulation of cytosolic calcium ion concentration|
|phagocytosis|
|regulation of cation transmembrane transport|
|regulation of epithelial cell proliferation|
|second-messenger-mediated signaling|
|glutamatergic synapse|
|axonogenesis|
|phospholipid metabolic process|
|in utero embryonic development|
|leukocyte migration|
|regulation of metal ion transport|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|organic hydroxy compound metabolic process|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|divalent inorganic cation homeostasis|
|cell projection morphogenesis|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|positive regulation of cell motility|
|response to growth factor|
|organophosphate biosynthetic process|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|small molecule biosynthetic process|
|immune response-regulating signaling pathway|
|cation transmembrane transport|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|chordate embryonic development|
|metal ion transport|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|neuron projection development|
|positive regulation of cell death|
|regulation of ion transport|
|viral process|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|calcium ion binding|
|cell morphogenesis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|symbiotic process|
|ion homeostasis|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|cation transport|
|regulation of cell migration|
|positive regulation of immune response|
|organophosphate metabolic process|
|cellular homeostasis|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|ion transmembrane transport|
|cellular lipid metabolic process|
|cell migration|
|embryo development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|immune effector process|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|transmembrane transport|
|locomotion|
|positive regulation of developmental process|
|ion transport|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.83|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5472
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLCG1 Expression in NALM6 Cells: 6.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>