PLCG1
Gene Information
- Official Symbol: PLCG1
- Official Name: phospholipase C gamma 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5335
- UniProt: P19174
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. {ECO:0000269|PubMed:17229814}.
Pfam Domains GO Terms
Pfam Domains
| SH2 |
| SH3 1 |
| C2 |
| PI-PLC-Y |
| PI-PLC-X |
| SH3 2 |
GO Terms
| neurotrophin TRKA receptor binding |
| glutamate receptor binding |
| phospholipase C activity |
| positive regulation of vascular endothelial cell proliferation |
| inositol trisphosphate biosynthetic process |
| positive regulation of endothelial cell apoptotic process |
| inositol trisphosphate metabolic process |
| regulation of vascular endothelial cell proliferation |
| phosphatidylinositol phospholipase C activity |
| inositol phosphate biosynthetic process |
| activation of phospholipase C activity |
| positive regulation of epithelial cell apoptotic process |
| phospholipid catabolic process |
| COP9 signalosome |
| positive regulation of release of sequestered calcium ion into cytosol |
| cellular response to epidermal growth factor stimulus |
| positive regulation of phospholipase C activity |
| regulation of phospholipase C activity |
| response to epidermal growth factor |
| regulation of endothelial cell apoptotic process |
| epidermal growth factor receptor signaling pathway |
| positive regulation of calcium ion transport into cytosol |
| release of sequestered calcium ion into cytosol |
| positive regulation of blood vessel endothelial cell migration |
| receptor tyrosine kinase binding |
| inositol phosphate metabolic process |
| negative regulation of sequestering of calcium ion |
| polyol biosynthetic process |
| positive regulation of phospholipase activity |
| calcium ion transmembrane import into cytosol |
| ERBB signaling pathway |
| positive regulation of calcium ion transmembrane transport |
| regulation of phospholipase activity |
| positive regulation of lipase activity |
| phosphatidylinositol-mediated signaling |
| calcium ion transport into cytosol |
| inositol lipid-mediated signaling |
| regulation of release of sequestered calcium ion into cytosol |
| regulation of epithelial cell apoptotic process |
| Schaffer collateral - CA1 synapse |
| cytosolic calcium ion transport |
| regulation of blood vessel endothelial cell migration |
| ruffle |
| positive regulation of endothelial cell proliferation |
| regulation of lipase activity |
| cell projection |
| regulation of calcium ion transport into cytosol |
| positive regulation of endothelial cell migration |
| polyol metabolic process |
| alcohol biosynthetic process |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| organophosphate catabolic process |
| regulation of endothelial cell proliferation |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| Fc-gamma receptor signaling pathway |
| positive regulation of epithelial cell migration |
| positive regulation of cation transmembrane transport |
| calcium-mediated signaling |
| regulation of calcium ion transmembrane transport |
| positive regulation of ion transmembrane transport |
| regulation of endothelial cell migration |
| positive regulation of angiogenesis |
| cell-cell junction |
| Fc-epsilon receptor signaling pathway |
| T cell receptor signaling pathway |
| lamellipodium |
| positive regulation of vasculature development |
| organic hydroxy compound biosynthetic process |
| positive regulation of epithelial cell proliferation |
| cellular lipid catabolic process |
| calcium ion transmembrane transport |
| positive regulation of transmembrane transport |
| regulation of epithelial cell migration |
| Fc receptor signaling pathway |
| regulation of calcium ion transport |
| calcium ion transport |
| axon guidance |
| neuron projection guidance |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| regulation of angiogenesis |
| antigen receptor-mediated signaling pathway |
| divalent metal ion transport |
| lipid catabolic process |
| divalent inorganic cation transport |
| alcohol metabolic process |
| regulation of vasculature development |
| regulation of cytosolic calcium ion concentration |
| phagocytosis |
| regulation of cation transmembrane transport |
| regulation of epithelial cell proliferation |
| second-messenger-mediated signaling |
| glutamatergic synapse |
| axonogenesis |
| phospholipid metabolic process |
| in utero embryonic development |
| leukocyte migration |
| regulation of metal ion transport |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| cellular calcium ion homeostasis |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| immune response-activating cell surface receptor signaling pathway |
| organic hydroxy compound metabolic process |
| protein kinase binding |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| neuron projection morphogenesis |
| immune response-regulating cell surface receptor signaling pathway |
| plasma membrane bounded cell projection morphogenesis |
| divalent inorganic cation homeostasis |
| cell projection morphogenesis |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| positive regulation of cell motility |
| response to growth factor |
| organophosphate biosynthetic process |
| positive regulation of cellular component movement |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| cell morphogenesis involved in differentiation |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| immune response-activating signal transduction |
| regulation of transmembrane transport |
| small molecule biosynthetic process |
| immune response-regulating signaling pathway |
| cation transmembrane transport |
| metal ion homeostasis |
| activation of immune response |
| cellular cation homeostasis |
| chordate embryonic development |
| metal ion transport |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| neuron projection development |
| positive regulation of cell death |
| regulation of ion transport |
| viral process |
| cation homeostasis |
| enzyme linked receptor protein signaling pathway |
| inorganic ion homeostasis |
| calcium ion binding |
| cell morphogenesis |
| cellular chemical homeostasis |
| positive regulation of hydrolase activity |
| symbiotic process |
| ion homeostasis |
| neuron development |
| interspecies interaction between organisms |
| cellular component morphogenesis |
| cation transport |
| regulation of cell migration |
| positive regulation of immune response |
| organophosphate metabolic process |
| cellular homeostasis |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| ion transmembrane transport |
| cellular lipid metabolic process |
| cell migration |
| embryo development |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| neuron differentiation |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| immune effector process |
| chemical homeostasis |
| plasma membrane bounded cell projection organization |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| regulation of hydrolase activity |
| transmembrane transport |
| locomotion |
| positive regulation of developmental process |
| ion transport |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| generation of neurons |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| neurogenesis |
| homeostatic process |
| cell development |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| establishment of localization in cell |
| regulation of transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pyronaridine 1μM R06 exp295 | -1.83 |
| BS-181 20μM R08 exp461 | -1.75 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5472
- Expression level (log2 read counts): 6.77
Expression Distribution
PLCG1 Expression in NALM6 Cells: 6.77
