PLCH1

Entrez Summary: N/A
UniProt Summary: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nutlin-3A 1.6μM R06 exp294	-2.24
GSK343 3μM R03 exp124	1.78

calcium-dependent phospholipase C activity
inositol trisphosphate biosynthetic process
inositol trisphosphate metabolic process
phosphatidylinositol phospholipase C activity
inositol phosphate biosynthetic process
release of sequestered calcium ion into cytosol
inositol phosphate metabolic process
negative regulation of sequestering of calcium ion
polyol biosynthetic process
calcium ion transmembrane import into cytosol
phosphatidylinositol-mediated signaling
calcium ion transport into cytosol
inositol lipid-mediated signaling
cytosolic calcium ion transport
polyol metabolic process
alcohol biosynthetic process
regulation of sequestering of calcium ion
organic hydroxy compound biosynthetic process
calcium ion transmembrane transport
calcium ion transport
positive regulation of cytosolic calcium ion concentration
divalent metal ion transport
lipid catabolic process
divalent inorganic cation transport
alcohol metabolic process
regulation of cytosolic calcium ion concentration
cellular calcium ion homeostasis
calcium ion homeostasis
organic hydroxy compound metabolic process
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
organophosphate biosynthetic process
cellular metal ion homeostasis
inorganic cation transmembrane transport
small molecule biosynthetic process
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis