PLCL1

Entrez Summary: N/A
UniProt Summary: Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. {ECO:0000250, ECO:0000269|PubMed:17254016}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phospholipase C activity
positive regulation of receptor binding
inositol 1,4,5 trisphosphate binding
inositol trisphosphate biosynthetic process
GABA receptor binding
inositol trisphosphate metabolic process
regulation of receptor binding
gamma-aminobutyric acid signaling pathway
phosphatidylinositol phospholipase C activity
inositol phosphate biosynthetic process
regulation of synaptic transmission, GABAergic
negative regulation of cold-induced thermogenesis
inositol phosphate metabolic process
polyol biosynthetic process
positive regulation of protein binding
polyol metabolic process
alcohol biosynthetic process
regulation of peptidyl-serine phosphorylation
regulation of cold-induced thermogenesis
positive regulation of binding
organic hydroxy compound biosynthetic process
regulation of protein binding
alcohol metabolic process
regulation of binding
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
organic hydroxy compound metabolic process
organophosphate biosynthetic process
small molecule biosynthetic process
organophosphate metabolic process
negative regulation of multicellular organismal process
lipid metabolic process
G protein-coupled receptor signaling pathway
regulation of protein phosphorylation
regulation of phosphorylation
intracellular signal transduction
small molecule metabolic process
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process