PLCL2 [The Human Chemical-Genetic Interaction Map Project]

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======= PLCL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLCL2
  * **<color #00a2e8>Official Name</color>**: phospholipase C like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23228|23228]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPR0|Q9UPR0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLCL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLCL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614276|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand like|
|C2|
|PI-PLC-X|
|PI-PLC-Y|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|B-1a B cell differentiation|
|B-1 B cell differentiation|
|B cell proliferation involved in immune response|
|negative regulation of B cell receptor signaling pathway|
|positive regulation of receptor binding|
|inositol 1,4,5 trisphosphate binding|
|inositol trisphosphate biosynthetic process|
|GABA receptor binding|
|inositol trisphosphate metabolic process|
|regulation of receptor binding|
|mature B cell differentiation|
|gamma-aminobutyric acid signaling pathway|
|phosphatidylinositol phospholipase C activity|
|regulation of B cell receptor signaling pathway|
|negative regulation of antigen receptor-mediated signaling pathway|
|inositol phosphate biosynthetic process|
|regulation of synaptic transmission, GABAergic|
|B cell proliferation|
|B cell activation involved in immune response|
|negative regulation of cold-induced thermogenesis|
|inositol phosphate metabolic process|
|polyol biosynthetic process|
|regulation of antigen receptor-mediated signaling pathway|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|positive regulation of protein binding|
|leukocyte proliferation|
|B cell differentiation|
|polyol metabolic process|
|lymphocyte activation involved in immune response|
|alcohol biosynthetic process|
|regulation of peptidyl-serine phosphorylation|
|regulation of cold-induced thermogenesis|
|B cell activation|
|positive regulation of binding|
|organic hydroxy compound biosynthetic process|
|regulation of protein binding|
|lymphocyte differentiation|
|alcohol metabolic process|
|leukocyte differentiation|
|regulation of binding|
|lymphocyte activation|
|negative regulation of immune system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic hydroxy compound metabolic process|
|organophosphate biosynthetic process|
|cell population proliferation|
|hemopoiesis|
|small molecule biosynthetic process|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|organophosphate metabolic process|
|leukocyte activation|
|cell activation|
|immune effector process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|intracellular signal transduction|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12215
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLCL2 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>