PLCL2
Gene Information
- Official Symbol: PLCL2
- Official Name: phospholipase C like 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 23228
- UniProt: Q9UPR0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| efhand like |
| C2 |
| PI-PLC-X |
| PI-PLC-Y |
GO Terms
| B-1a B cell differentiation |
| B-1 B cell differentiation |
| B cell proliferation involved in immune response |
| negative regulation of B cell receptor signaling pathway |
| positive regulation of receptor binding |
| inositol 1,4,5 trisphosphate binding |
| inositol trisphosphate biosynthetic process |
| GABA receptor binding |
| inositol trisphosphate metabolic process |
| regulation of receptor binding |
| mature B cell differentiation |
| gamma-aminobutyric acid signaling pathway |
| phosphatidylinositol phospholipase C activity |
| regulation of B cell receptor signaling pathway |
| negative regulation of antigen receptor-mediated signaling pathway |
| inositol phosphate biosynthetic process |
| regulation of synaptic transmission, GABAergic |
| B cell proliferation |
| B cell activation involved in immune response |
| negative regulation of cold-induced thermogenesis |
| inositol phosphate metabolic process |
| polyol biosynthetic process |
| regulation of antigen receptor-mediated signaling pathway |
| lymphocyte proliferation |
| mononuclear cell proliferation |
| positive regulation of protein binding |
| leukocyte proliferation |
| B cell differentiation |
| polyol metabolic process |
| lymphocyte activation involved in immune response |
| alcohol biosynthetic process |
| regulation of peptidyl-serine phosphorylation |
| regulation of cold-induced thermogenesis |
| B cell activation |
| positive regulation of binding |
| organic hydroxy compound biosynthetic process |
| regulation of protein binding |
| lymphocyte differentiation |
| alcohol metabolic process |
| leukocyte differentiation |
| regulation of binding |
| lymphocyte activation |
| negative regulation of immune system process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| organic hydroxy compound metabolic process |
| organophosphate biosynthetic process |
| cell population proliferation |
| hemopoiesis |
| small molecule biosynthetic process |
| hematopoietic or lymphoid organ development |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| immune system development |
| organophosphate metabolic process |
| leukocyte activation |
| cell activation |
| immune effector process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| negative regulation of signal transduction |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| intracellular signal transduction |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| THZ531 0.11 to 0.175μM on day4 R07 exp413 | 1.89 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12215
- Expression level (log2 read counts): 5.89
Expression Distribution
PLCL2 Expression in NALM6 Cells: 5.89
