PLEK2

Entrez Summary: N/A
UniProt Summary: May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PH
DEP

lamellipodium membrane
phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-3,4-bisphosphate binding
phosphatidylinositol-3-phosphate binding
actin cytoskeleton reorganization
positive regulation of plasma membrane bounded cell projection assembly
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
cytoskeleton
positive regulation of cell projection organization
actin cytoskeleton organization
positive regulation of cellular component biogenesis
actin filament-based process
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of cellular component biogenesis
cytoskeleton organization
positive regulation of cellular component organization
intracellular signal transduction