PLEKHA3 [The Human Chemical-Genetic Interaction Map Project]

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======= PLEKHA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLEKHA3
  * **<color #00a2e8>Official Name</color>**: pleckstrin homology domain containing A3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65977|65977]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HB20|Q9HB20]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLEKHA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLEKHA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607774|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P). {ECO:0000269|PubMed:15107860}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ER to Golgi ceramide transport|
|ceramide 1-phosphate binding|
|ceramide 1-phosphate transfer activity|
|intermembrane lipid transfer|
|ceramide 1-phosphate transport|
|ceramide transport|
|phosphatidylinositol-4-phosphate binding|
|intracellular lipid transport|
|phospholipid transport|
|phosphatidylinositol biosynthetic process|
|organophosphate ester transport|
|lipid binding|
|phosphatidylinositol metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|lipid transport|
|glycerophospholipid metabolic process|
|lipid localization|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organic anion transport|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|anion transport|
|Golgi membrane|
|membrane organization|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|Golgi apparatus|
|lipid metabolic process|
|ion transport|
|intracellular transport|
|amide transport|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.29|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-2.31|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.84|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.75|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.77|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.79|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.86|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.91|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15016
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLEKHA3 Expression in NALM6 Cells: 4.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>