PLEKHA3

Entrez Summary: N/A
UniProt Summary: Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P). {ECO:0000269|PubMed:15107860}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ER to Golgi ceramide transport
ceramide 1-phosphate binding
ceramide 1-phosphate transfer activity
intermembrane lipid transfer
ceramide 1-phosphate transport
ceramide transport
phosphatidylinositol-4-phosphate binding
intracellular lipid transport
phospholipid transport
phosphatidylinositol biosynthetic process
organophosphate ester transport
lipid binding
phosphatidylinositol metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
lipid transport
glycerophospholipid metabolic process
lipid localization
phospholipid metabolic process
glycerolipid metabolic process
organic anion transport
organophosphate biosynthetic process
lipid biosynthetic process
anion transport
Golgi membrane
membrane organization
organophosphate metabolic process
cellular lipid metabolic process
Golgi apparatus
lipid metabolic process
ion transport
intracellular transport
amide transport
establishment of localization in cell
nitrogen compound transport