PLEKHA4 [The Human Chemical-Genetic Interaction Map Project]

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======= PLEKHA4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLEKHA4
  * **<color #00a2e8>Official Name</color>**: pleckstrin homology domain containing A4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57664|57664]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H4M7|Q9H4M7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLEKHA4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLEKHA4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607769|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of Wnt signaling pathway, planar cell polarity pathway|
|positive regulation of non-canonical Wnt signaling pathway|
|regulation of Wnt signaling pathway, planar cell polarity pathway|
|regulation of non-canonical Wnt signaling pathway|
|phosphatidylinositol-3,5-bisphosphate binding|
|phosphatidylinositol-3,4-bisphosphate binding|
|phosphatidylinositol-3-phosphate binding|
|extrinsic component of cytoplasmic side of plasma membrane|
|phosphatidylinositol-4,5-bisphosphate binding|
|phosphatidylinositol biosynthetic process|
|regulation of establishment of planar polarity|
|positive regulation of canonical Wnt signaling pathway|
|phosphatidylinositol metabolic process|
|positive regulation of Wnt signaling pathway|
|regulation of morphogenesis of an epithelium|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|regulation of animal organ morphogenesis|
|regulation of canonical Wnt signaling pathway|
|glycerophospholipid metabolic process|
|regulation of Wnt signaling pathway|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|cellular component|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|regulation of anatomical structure morphogenesis|
|lipid metabolic process|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.7|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.73|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.78|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.82|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.82|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.83|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.84|
|[[:results:exp303|39°C R06 exp303]]|1.86|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.96|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.03|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.05|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.09|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ik|IK]]|0.486|
|[[:human genes:t:tceb3c|TCEB3C]]|0.46|
|[[:human genes:u:utp3|UTP3]]|0.455|
|[[:human genes:d:dtl|DTL]]|0.455|
|[[:human genes:t:tfip11|TFIP11]]|0.454|
|[[:human genes:o:orc6|ORC6]]|0.454|
|[[:human genes:d:dock6|DOCK6]]|0.45|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.448|
|[[:human genes:p:psmb4|PSMB4]]|0.447|
|[[:human genes:s:sec13|SEC13]]|0.443|
|[[:human genes:c:cep192|CEP192]]|0.44|
|[[:human genes:n:npipb5|NPIPB5]]|0.439|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.437|
|[[:human genes:c:cln6|CLN6]]|0.436|
|[[:human genes:c:cdca3|CDCA3]]|0.436|
|[[:human genes:r:rps12|RPS12]]|0.434|
|[[:human genes:s:sap30bp|SAP30BP]]|0.431|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.429|
|[[:human genes:c:cdc6|CDC6]]|0.429|
|[[:human genes:p:psmd3|PSMD3]]|0.427|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.427|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.422|
|[[:human genes:n:npipb3|NPIPB3]]|0.422|
|[[:human genes:t:tspy8|TSPY8]]|0.42|
|[[:human genes:c:cnot3|CNOT3]]|0.419|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.419|
|[[:human genes:s:sf3a1|SF3A1]]|0.419|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.417|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.416|
|[[:human genes:r:rps2|RPS2]]|0.414|
|[[:human genes:s:sf3a2|SF3A2]]|0.412|
|[[:human genes:c:cdh24|CDH24]]|0.412|
|[[:human genes:e:eif3g|EIF3G]]|0.412|
|[[:human genes:u:usp35|USP35]]|0.412|
|[[:human genes:c:cbwd6|CBWD6]]|0.411|
|[[:human genes:p:psmb2|PSMB2]]|0.411|
|[[:human genes:g:gid4|GID4]]|0.41|
|[[:human genes:t:tyms|TYMS]]|0.409|
|[[:human genes:p:pold1|POLD1]]|0.408|
|[[:human genes:p:pole|POLE]]|0.408|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.408|
|[[:human genes:c:copg1|COPG1]]|0.405|
|[[:human genes:p:pdcd7|PDCD7]]|0.404|
|[[:human genes:c:c14orf93|C14orf93]]|0.404|
|[[:human genes:p:prpf3|PRPF3]]|0.402|
|[[:human genes:b:bysl|BYSL]]|0.402|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.402|
|[[:human genes:g:golga8j|GOLGA8J]]|0.401|
|[[:human genes:f:fam231c|FAM231C]]|0.4|
|[[:human genes:r:rpl35|RPL35]]|0.4|
|[[:human genes:f:fam231a|FAM231A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1994
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.91 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLEKHA4 Expression in NALM6 Cells: 0.91'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>