PLEKHA4

Entrez Summary: This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017].
UniProt Summary: Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 0.1μM R01 exp49	1.7
Alpha-Amanitin 0.5μM R00 exp5	1.73
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.78
CCCP 0.1μM R00 exp10	1.82
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.82
Cycloheximide 0.2μM R00 exp15	1.83
TNF-alpha 44ng/ml R08 exp533	1.84
39°C R06 exp303	1.86
Wortmannin 5μM R00 exp38	1.96
Doxycycline 10μM R00 exp18	2.03
Cycloheximide 0.02μM R00 exp14	2.05
Pimelic-diphenylamide-106 0.5μM R00 exp27	2.09
DABN 2μM R00 exp16	2.48

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of Wnt signaling pathway, planar cell polarity pathway
positive regulation of non-canonical Wnt signaling pathway
regulation of Wnt signaling pathway, planar cell polarity pathway
regulation of non-canonical Wnt signaling pathway
phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-3,4-bisphosphate binding
phosphatidylinositol-3-phosphate binding
extrinsic component of cytoplasmic side of plasma membrane
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol biosynthetic process
regulation of establishment of planar polarity
positive regulation of canonical Wnt signaling pathway
phosphatidylinositol metabolic process
positive regulation of Wnt signaling pathway
regulation of morphogenesis of an epithelium
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
regulation of animal organ morphogenesis
regulation of canonical Wnt signaling pathway
glycerophospholipid metabolic process
regulation of Wnt signaling pathway
phospholipid metabolic process
glycerolipid metabolic process
cellular component
organophosphate biosynthetic process
lipid biosynthetic process
organophosphate metabolic process
cellular lipid metabolic process
regulation of anatomical structure morphogenesis
lipid metabolic process
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling