PLEKHB2

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
5-Fluorouracil 20μM R00 exp2	-1.71
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.71
Golgicide-A 4μM R03 exp122	1.75
UM0131023 0.05μM R05 exp248	1.76
ABT-702 5μM R07 exp318	1.82
BI-2536 0.0042μM R03 exp95	2.3

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylinositol-3,4,5-trisphosphate binding
recycling endosome membrane
regulation of cell differentiation