PLOD3

Entrez Summary: The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008].
UniProt Summary: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. {ECO:0000250|UniProtKB:P24802}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

procollagen galactosyltransferase activity
procollagen glucosyltransferase activity
hydroxylysine biosynthetic process
hydroxylysine metabolic process
procollagen-lysine 5-dioxygenase activity
peptidyl-lysine hydroxylation
basement membrane assembly
endothelial cell morphogenesis
L-ascorbic acid binding
basement membrane organization
protein hydroxylation
aspartate family amino acid biosynthetic process
epidermis morphogenesis
vasodilation
epithelial cell morphogenesis
lung morphogenesis
cellular modified amino acid biosynthetic process
collagen fibril organization
endothelial cell development
aspartate family amino acid metabolic process
positive regulation of blood vessel diameter
rough endoplasmic reticulum
alpha-amino acid biosynthetic process
collagen metabolic process
cellular amino acid biosynthetic process
endothelial cell differentiation
endothelium development
protein O-linked glycosylation
iron ion binding
regulation of blood vessel diameter
regulation of tube diameter
regulation of tube size
neural tube development
vascular process in circulatory system
lung development
trans-Golgi network
respiratory tube development
epithelial cell development
respiratory system development
cellular modified amino acid metabolic process