PLP1

Entrez Summary: This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015].
UniProt Summary: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

structural constituent of myelin sheath
axon ensheathment in central nervous system
central nervous system myelination
long-chain fatty acid biosynthetic process
myelin sheath
astrocyte development
oligodendrocyte development
substantia nigra development
astrocyte differentiation
neural nucleus development
oligodendrocyte differentiation
midbrain development
integrin-mediated signaling pathway
myelination
glial cell development
ensheathment of neurons
axon ensheathment
long-chain fatty acid metabolic process
fatty acid biosynthetic process
glial cell differentiation
monocarboxylic acid biosynthetic process
structural molecule activity
gliogenesis
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
axon development
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
synaptic signaling
inflammatory response
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
neuron projection development
brain development
head development
neuron development
carboxylic acid metabolic process