PLSCR1

Entrez Summary: N/A
UniProt Summary: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylserine biosynthetic process
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
regulation of DNA topoisomerase (ATP-hydrolyzing) activity
CD4 receptor binding
regulation of isomerase activity
positive regulation of isomerase activity
phospholipid scramblase activity
regulation of Fc receptor mediated stimulatory signaling pathway
plasma membrane phospholipid scrambling
response to interferon-beta
phosphatidylserine metabolic process
epidermal growth factor receptor binding
acute-phase response
phospholipid translocation
lipid translocation
regulation of mast cell activation
cellular modified amino acid biosynthetic process
regulation of membrane lipid distribution
positive regulation of ATPase activity
negative regulation of viral genome replication
acute inflammatory response
negative regulation of viral life cycle
regulation of ATPase activity
phospholipid transport
plasma membrane organization
regulation of viral genome replication
negative regulation of viral process
organophosphate ester transport
SH3 domain binding
platelet activation
regulation of viral life cycle
defense response to virus
cellular modified amino acid metabolic process
regulation of viral process
glycerophospholipid biosynthetic process
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
glycerolipid biosynthetic process
membrane raft
phospholipid biosynthetic process