PLTP

Entrez Summary: The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

LBP BPI CETP
LBP BPI CETP C

phosphatidylethanolamine transfer activity
vitamin E biosynthetic process
ceramide transfer activity
vitamin E metabolic process
phosphatidylglycerol binding
ceramide binding
phosphatidic acid transfer activity
fat-soluble vitamin biosynthetic process
phosphatidylcholine transporter activity
phosphatidylethanolamine binding
diacylglycerol binding
ceramide transport
phospholipid transporter activity
positive regulation of cholesterol efflux
vitamin biosynthetic process
high-density lipoprotein particle remodeling
phosphatidic acid binding
high-density lipoprotein particle
positive regulation of cholesterol transport
regulation of cholesterol efflux
positive regulation of sterol transport
protein-lipid complex remodeling
plasma lipoprotein particle remodeling
phosphatidylcholine binding
protein-containing complex remodeling
lipid transporter activity
fat-soluble vitamin metabolic process
plasma lipoprotein particle organization
regulation of cholesterol transport
regulation of sterol transport
protein-lipid complex subunit organization
positive regulation of lipid transport
flagellated sperm motility
sperm motility
regulation of plasma lipoprotein particle levels
positive regulation of lipid localization
phospholipid transport
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
regulation of lipid transport