PLXNA4

Entrez Summary: N/A
UniProt Summary: Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
I-BRD9 4μM R07 exp365	1.76
Nifurtimox 1μM R03 exp141	2.15

chemorepulsion of branchiomotor axon
vagus nerve morphogenesis
postganglionic parasympathetic fiber development
vagus nerve development
regulation of negative chemotaxis
glossopharyngeal nerve morphogenesis
trigeminal nerve structural organization
anterior commissure morphogenesis
trigeminal nerve morphogenesis
glossopharyngeal nerve development
branchiomotor neuron axon guidance
chemorepulsion of axon
facial nerve structural organization
semaphorin receptor complex
cranial nerve structural organization
facial nerve morphogenesis
facial nerve development
semaphorin-plexin signaling pathway involved in axon guidance
trigeminal nerve development
semaphorin receptor activity
semaphorin-plexin signaling pathway involved in neuron projection guidance
anatomical structure arrangement
preganglionic parasympathetic fiber development
parasympathetic nervous system development
sympathetic nervous system development
central nervous system projection neuron axonogenesis
motor neuron axon guidance
cranial nerve morphogenesis
regulation of axon extension involved in axon guidance
central nervous system neuron axonogenesis
semaphorin-plexin signaling pathway
regulation of axon guidance
negative chemotaxis
autonomic nervous system development
cranial nerve development
peripheral nervous system development
nerve development
central nervous system neuron development
positive regulation of axonogenesis
regulation of axon extension