PLXNB1
Gene Information
- Official Symbol: PLXNB1
- Official Name: plexin B1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5364
- UniProt: O43157
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. {ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496, ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}.
Pfam Domains GO Terms
Pfam Domains
| TIG |
| Plexin cytopl |
| PSI |
| Sema |
GO Terms
| semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis |
| inhibitory synapse assembly |
| negative regulation of osteoblast proliferation |
| bone trabecula morphogenesis |
| semaphorin receptor complex |
| semaphorin-plexin signaling pathway involved in axon guidance |
| semaphorin receptor activity |
| semaphorin-plexin signaling pathway involved in neuron projection guidance |
| ossification involved in bone maturation |
| GTPase activating protein binding |
| bone maturation |
| animal organ maturation |
| regulation of osteoblast proliferation |
| semaphorin receptor binding |
| semaphorin-plexin signaling pathway |
| trabecula morphogenesis |
| positive regulation of axonogenesis |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| synapse assembly |
| regulation of phosphatidylinositol 3-kinase signaling |
| anatomical structure maturation |
| transmembrane signaling receptor activity |
| regulation of cell shape |
| positive regulation of cell morphogenesis involved in differentiation |
| regulation of axonogenesis |
| bone development |
| signaling receptor activity |
| developmental maturation |
| axon guidance |
| neuron projection guidance |
| ossification |
| synapse organization |
| negative regulation of cell adhesion |
| positive regulation of neuron projection development |
| GTPase activator activity |
| regulation of cell morphogenesis involved in differentiation |
| positive regulation of neuron differentiation |
| axonogenesis |
| positive regulation of cell projection organization |
| axon development |
| positive regulation of GTPase activity |
| cell morphogenesis involved in neuron differentiation |
| positive regulation of neurogenesis |
| neuron projection morphogenesis |
| regulation of GTPase activity |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of cell morphogenesis |
| skeletal system development |
| regulation of neuron projection development |
| cell part morphogenesis |
| positive regulation of nervous system development |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| regulation of neuron differentiation |
| neuron projection development |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| cell morphogenesis |
| positive regulation of hydrolase activity |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cell migration |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| cell migration |
| positive regulation of cell differentiation |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| positive regulation of intracellular signal transduction |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of cellular component organization |
| regulation of hydrolase activity |
| regulation of organelle organization |
| locomotion |
| G protein-coupled receptor signaling pathway |
| positive regulation of developmental process |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| generation of neurons |
| movement of cell or subcellular component |
| regulation of cell population proliferation |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Tubacin 1.6μM R07 exp416 | -1.88 |
| Fas-L 44ng/ml R08 exp482 | 1.71 |
| Ethanol 0.003 R08 exp437 | 1.76 |
| Apcin 50 to 100μM on day4 R04 exp176 | 1.97 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5041
- Expression level (log2 read counts): 4.33
Expression Distribution
PLXNB1 Expression in NALM6 Cells: 4.33
