PLXNB2 [The Human Chemical-Genetic Interaction Map Project]

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======= PLXNB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLXNB2
  * **<color #00a2e8>Official Name</color>**: plexin B2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23654|23654]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15031|O15031]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLXNB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLXNB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604293|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro) (By similarity). {ECO:0000250, ECO:0000269|PubMed:12183458, ECO:0000269|PubMed:12533544, ECO:0000269|PubMed:15184888}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PSI|
|Sema|
|Plexin cytopl|
|TIG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|semaphorin receptor complex|
|semaphorin-plexin signaling pathway involved in axon guidance|
|semaphorin receptor activity|
|semaphorin-plexin signaling pathway involved in neuron projection guidance|
|excitatory synapse assembly|
|neuroblast proliferation|
|semaphorin-plexin signaling pathway|
|regulation of neuron migration|
|stem cell proliferation|
|neural precursor cell proliferation|
|positive regulation of axonogenesis|
|neural tube closure|
|tube closure|
|synapse assembly|
|primary neural tube formation|
|neural tube formation|
|embryonic epithelial tube formation|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|regulation of cell shape|
|positive regulation of cell morphogenesis involved in differentiation|
|neural tube development|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|regulation of axonogenesis|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|axon guidance|
|neuron projection guidance|
|synapse organization|
|negative regulation of cell adhesion|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|positive regulation of neuron differentiation|
|axonogenesis|
|positive regulation of cell projection organization|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|cell surface|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.85|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5646
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLXNB2 Expression in NALM6 Cells: 5.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>