PLXNB2

Entrez Summary: N/A
UniProt Summary: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro) (By similarity). {ECO:0000250, ECO:0000269|PubMed:12183458, ECO:0000269|PubMed:12533544, ECO:0000269|PubMed:15184888}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Lead acetate 990μM R08 exp496	1.85
GSK-J4 1μM R07 exp362	1.95

semaphorin receptor complex
semaphorin-plexin signaling pathway involved in axon guidance
semaphorin receptor activity
semaphorin-plexin signaling pathway involved in neuron projection guidance
excitatory synapse assembly
neuroblast proliferation
semaphorin-plexin signaling pathway
regulation of neuron migration
stem cell proliferation
neural precursor cell proliferation
positive regulation of axonogenesis
neural tube closure
tube closure
synapse assembly
primary neural tube formation
neural tube formation
embryonic epithelial tube formation
epithelial tube formation
morphogenesis of embryonic epithelium
tube formation
regulation of cell shape
positive regulation of cell morphogenesis involved in differentiation
neural tube development
homophilic cell adhesion via plasma membrane adhesion molecules
regulation of axonogenesis
cell-cell adhesion via plasma-membrane adhesion molecules
axon guidance
neuron projection guidance
synapse organization
negative regulation of cell adhesion
positive regulation of neuron projection development
regulation of cell morphogenesis involved in differentiation
epithelial tube morphogenesis
positive regulation of neuron differentiation
axonogenesis
positive regulation of cell projection organization
axon development
cell morphogenesis involved in neuron differentiation
morphogenesis of an epithelium
positive regulation of neurogenesis