PNKD [The Human Chemical-Genetic Interaction Map Project]

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======= PNKD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PNKD
  * **<color #00a2e8>Official Name</color>**: PNKD metallo-beta-lactamase domain containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25953|25953]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N490|Q8N490]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PNKD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PNKD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609023|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lactamase B 2|
|Lactamase B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione|
|methylglyoxal catabolic process|
|hydroxyacylglutathione hydrolase activity|
|methylglyoxal catabolic process to lactate|
|methylglyoxal metabolic process|
|ketone catabolic process|
|aldehyde catabolic process|
|negative regulation of neurotransmitter secretion|
|lactate metabolic process|
|regulation of synaptic transmission, dopaminergic|
|neuromuscular process controlling posture|
|regulation of dopamine metabolic process|
|regulation of catecholamine metabolic process|
|negative regulation of neurotransmitter transport|
|cellular aldehyde metabolic process|
|negative regulation of synaptic transmission|
|cellular ketone metabolic process|
|regulation of cellular amine metabolic process|
|regulation of neurotransmitter secretion|
|neuromuscular process|
|regulation of neurotransmitter transport|
|negative regulation of secretion by cell|
|negative regulation of secretion|
|regulation of neurotransmitter levels|
|small molecule catabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic hydroxy compound metabolic process|
|negative regulation of transport|
|monocarboxylic acid metabolic process|
|regulation of secretion by cell|
|regulation of secretion|
|carboxylic acid metabolic process|
|regulation of cellular localization|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4622
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PNKD Expression in NALM6 Cells: 3.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>