PNKD

Entrez Summary: This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
UniProt Summary: Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Lactamase B 2
Lactamase B

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
methylglyoxal catabolic process
hydroxyacylglutathione hydrolase activity
methylglyoxal catabolic process to lactate
methylglyoxal metabolic process
ketone catabolic process
aldehyde catabolic process
negative regulation of neurotransmitter secretion
lactate metabolic process
regulation of synaptic transmission, dopaminergic
neuromuscular process controlling posture
regulation of dopamine metabolic process
regulation of catecholamine metabolic process
negative regulation of neurotransmitter transport
cellular aldehyde metabolic process
negative regulation of synaptic transmission
cellular ketone metabolic process
regulation of cellular amine metabolic process
regulation of neurotransmitter secretion
neuromuscular process
regulation of neurotransmitter transport
negative regulation of secretion by cell
negative regulation of secretion
regulation of neurotransmitter levels
small molecule catabolic process
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
organic hydroxy compound metabolic process
negative regulation of transport
monocarboxylic acid metabolic process
regulation of secretion by cell
regulation of secretion
carboxylic acid metabolic process
regulation of cellular localization
oxoacid metabolic process
organic acid metabolic process
mitochondrion
negative regulation of cell communication
negative regulation of signaling
nervous system process