PNLDC1 [The Human Chemical-Genetic Interaction Map Project]

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======= PNLDC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PNLDC1
  * **<color #00a2e8>Official Name</color>**: PARN like, ribonuclease domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=154197|154197]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NA58|Q8NA58]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PNLDC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PNLDC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619529|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:B2RXZ1, ECO:0000269|PubMed:27515512}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAF1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|poly(A)-specific ribonuclease activity|
|nuclear-transcribed mRNA poly(A) tail shortening|
|3-5-exoribonuclease activity|
|blastocyst formation|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|blastocyst development|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|RNA phosphodiester bond hydrolysis|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|nucleobase-containing compound catabolic process|
|in utero embryonic development|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|mRNA metabolic process|
|anatomical structure formation involved in morphogenesis|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|embryo development|
|endoplasmic reticulum|
|macromolecule catabolic process|
|RNA binding|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp302|35°C R06 exp302]]|-2.03|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.84|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.71|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13880
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PNLDC1 Expression in NALM6 Cells: -2.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>