PNLDC1

Entrez Summary: N/A
UniProt Summary: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:B2RXZ1, ECO:0000269|PubMed:27515512}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

poly(A)-specific ribonuclease activity
nuclear-transcribed mRNA poly(A) tail shortening
3-5-exoribonuclease activity
blastocyst formation
RNA phosphodiester bond hydrolysis, exonucleolytic
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
blastocyst development
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
RNA phosphodiester bond hydrolysis
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
RNA catabolic process
nucleic acid phosphodiester bond hydrolysis
nucleobase-containing compound catabolic process
in utero embryonic development
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
chordate embryonic development
embryo development ending in birth or egg hatching
mRNA metabolic process
anatomical structure formation involved in morphogenesis
cellular macromolecule catabolic process
endoplasmic reticulum membrane
embryo development
endoplasmic reticulum
macromolecule catabolic process
RNA binding
RNA metabolic process
negative regulation of gene expression
organic substance catabolic process
cellular catabolic process